Patient FAQ's - Triferic
How will Triferic benefit me?

Triferic replaces the iron you lose during every dialysis treatment and stabilizes your hemoglobin levels, without leading to excess iron being trapped in your body. Triferic will enable you to quit receiving IV iron as a maintenance therapy. Some patients using Triferic have reported having more energy. In clinical trials, it has been shown to reduce the amount of other anemia medicines such as erythropoiesis-stimulating agents (ESAs), and blood transfusions, relative to placebo.

How is this different from what I am getting right now?

Triferic is an iron maintenance therapy. It replaces the iron you lose during each dialysis session, which is about 5-7 mg. You receive Triferic consistently during your 3-4 hour dialysis treatment. There are no needles or syringes; you won’t even know your receiving it. As soon as Triferic enters your blood it binds immediately to transferrin (the natural carrier of iron in the body), where it is taken to your bone marrow to help make red blood cells. This is similar to the slower, natural manner in which iron is processed in the body to maintain hemoglobin.

In contrast, IV iron is administered in a large dose quickly over a few minutes once per week, bi-weekly or at longer intervals, and instead of binding immediately to transferrin and going to your bone marrow, the majority gets trapped in your liver, leading to an increase in stored iron and inflammation. IV iron is associated with an increased risk for infections and severe life threatening hypersensitivity reactions. IV iron is not FDA approved as an iron maintenance therapy to replace iron and maintain Hgb.

IV iron has been known to cause serious, life-threatening hypersensitivity reactions, does Triferic?

No, Triferic does not because it does not have a carbohydrate moiety and it is administered very slowly. Triferic has been studied in about 1500 patients in over 100,000 doses administered and there have been no severe life threatening hypersensitivity reactions. In fact, patients with history of hypersensitivity reactions to IV iron products participated in clinical trials of Triferic and tolerated Triferic well.

How do I get Triferic?

Your doctor prescribes Triferic for you, and it will be added to your dialysis solution (dialysate) and you will receive it slowly throughout each dialysis session. There will be no needles or IV’s.

Will I need to pay for Triferic out of pocket?

There are no out-of-pocket costs to you. Triferic is covered by your insurance.

I have had an allergic reaction to IV iron before so can I still take Triferic?

Yes. Patients with a history of allergy to IV iron received Triferic in clinical trials and did not report any symptoms similar to their experience with IV iron.

Adverse Reactions

The most common adverse reactions in controlled clinical studies include: headache, peripheral edema, asthenia, AV fistula thrombosis, urinary tract infection, AV fistula site hemorrhage, pyrexia, fatigue, procedural hypotension, muscle spasms, pain in extremity, back pain, and dyspnea. To report SUSPECTED ADVERSE REACTIONS, contact Rockwell Medical at 1-855-333-4315 or 1-248-960-9009 or FDA at 1-800-FDA-1088 or

Will Triferic interfere with my other medications?

No, Triferic will not interfere with any of your other medications. You may take all of your usual medications the way you usually do.

Will Triferic change my dialysis treatment in any way?

Triferic will not change your dialysis treatment schedule or duration. Triferic may help improve your energy level and how you feel post-dialysis.

How do I order Triferic?

If you are looking to purchase Triferic or need more information, please contact our sales team at

View our patient brochure and video below or ask your doctor about Triferic


Patient Brochure

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